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Astrocytes

Astrocytes are the most abundant glial cells in the central nervous system. Besides their general supportive role to the central nervous system, astrocytes serve many housekeeping functions, including maintenance of neuronal metabolism and neurotransmitter synthesis, connection between neuronal activity and cerebral blood flow, modulation of synaptic function through glutamate transporters, and stimulation of adult neurogenesis upon injury, etc. Many central nervous system disorders have been associated with abnormalities in astrocytes, such as amyotrophic lateral sclerosis, Alzheimer’s disease, Parkinson’s disease, and Huntington disease.

XCell has developed a proprietary process to produce high quality and large quantities of astrocytes from human induced pluripotent stem cells (hiPSCs). These astrocytes possess major functionalities of primary human astrocytes and thus are suitable for a variety of applications:

  • Use as source material to study metabolism, synapses, gene expression, proteomics, and epigenetics in human astrocytes
  • Use alone or co-culture with neuronal cells to build physiologically relevant in vitro cellular models for drug screening and neurotoxicity tests
  • Build disease models for mechanism studies of a variety of central nervous system disorders
  • Co-deliver with neuronal cells to increase survival rate of neurons in cell therapy studies

Control Lines

Product Description Reprogram Method Source
XCL-1 Male Control Line Episomal Vectors Cord blood cells CD34+
XCL-6 Female Control Line Episomal Vectors Cord blood cells CD34+

Knockout Lines

Product Description Associated Disease Parental Line
SOD1-/- Custom Request ALS XCL-1
SOD1+/- Custom Request ALS XCL-1
APOE-/- Custom Request Alzheimer's Disease XCL-1
CNTNAP2-/- Custom Request Autism XCL-1
CNTNAP2 +/- Custom Request Autism XCL-1
BDNF-/- Custom Request CNS in General XCL-1
LRRK2-/- Custom Request Parkinson's Disease XCL-1
LRRK2+/- Custom Request Parkinson's Disease XCL-1
PARK2-/- Custom Request Parkinson's Disease XCL-1
PARK2+/- Custom Request Parkinson's Disease XCL-1
PINK1 -/- Custom Request Parkinson's Disease XCL-1
PINK1+/- Custom Request Parkinson's Disease XCL-1
PARK7-/- Custom Request Parkinson's Disease XCL-1
PARK7+/- Custom Request Parkinson's Disease XCL-1
PARK2-/-;PINK1-/- Custom Request Parkinson's Disease XCL-1
PARK2-/-;PARK7-/- Custom Request Parkinson's Disease XCL-1
DISC1-/- Custom Request Schizophrenia XCL-1

Reporter Lines

Product Description Parental Line
AAVS-DCX-GFP Custom Request XCL-1
CAG-GFP-chr13-hetero Custom Request XCL-1
CAG-GFP13-RFP19-hetero Custom Request XCL-1
CAG-GFP-chr19-homo Custom Request XCL-1
CAG-GFP-chr19-hetero Custom Request XCL-1
GFAP-NanolucHalotag-hetero Custom Request XCL-1
MAP2-NanolucHalotag-hetero Custom Request XCL-1