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Dopaminergic Neurons

XCell derives midbrain dopaminergic neurons using a two step protocol to reduce potential contamination from sympathetic adrenergic neurons and cortical dopaminergic neurons which are common contaminants in the direct differentiation process. After biasing NSC production to a midbrain phenotype, dopaminergic neurons are generated using a standardized protocol which gives us 30% or great dopaminergic neurons. Cells are supplied as a mixed population of neurons and glial precursors as this allows long-term maintenance of the cells in culture  (as long as a 100 days) and develop spiking activity that is characteristic of mature dopaminergic neurons.  Our dopaminergic neurons are supplied as a progenitor population to enable plating in a variety of formats including 96 well plates to ensure  consistency in  screening  experiments. Purified dopaminergic neurons can be supplied as a custom request . We can also derive dopmainergic neurons from any of the iPSC lines listed in our catalogue or from your line as a custom order.
 

Control Lines

Product Description Reprogram Method Source
XCL-1 Male Control Line Episomal Vectors Cord blood cells CD34+
XCL-6 Female Control Line Episomal Vectors Cord blood cells CD34+

Knockout Lines

Product Description Associated Disease Parental Line
SOD1-/- Custom Request ALS XCL-1
SOD1+/- Custom Request ALS XCL-1
APOE-/- Custom Request Alzheimer's Disease XCL-1
CNTNAP2 +/- Custom Request Autism XCL-1
CNTNAP2-/- Custom Request Autism XCL-1
BDNF-/- Custom Request CNS in General XCL-1
BDNF+/- Custom Request CNS in General XCL-1
LRRK2-/- Custom Request Parkinson's Disease XCL-1
LRRK2+/- Custom Request Parkinson's Disease XCL-1
PARK2-/- Custom Request Parkinson's Disease XCL-1
PARK2+/- Custom Request Parkinson's Disease XCL-1
PINK1 -/- Custom Request Parkinson's Disease XCL-1
PINK1+/- Custom Request Parkinson's Disease XCL-1
PARK7-/- Custom Request Parkinson's Disease XCL-1
PARK7+/- Custom Request Parkinson's Disease XCL-1
PARK2-/-;PINK1-/- Custom Request Parkinson's Disease XCL-1
PARK2-/-;PARK7-/- Custom Request Parkinson's Disease XCL-1
DISC1-/- Custom Request Schizophrenia XCL-1

Reporter Lines

Product Description Parental Line
AAVS-DCX-GFP Custom Request XCL-1
GFAP-NanolucHalotag-hetero Custom Request XCL-1
CAG-GFP-chr13-hetero Custom Request XCL-1
CAG-GFP13-RFP19-hetero Custom Request XCL-1
CAG-GFP-chr19-hetero Custom Request XCL-1
CAG-GFP-chr19-homo Custom Request XCL-1
MAP2-NanolucHalotag-hetero Custom Request XCL-1