Image

Neurons

XCell provides a mixed population of glutaminergic and GABA’ergic neurons of the cortical phenotype. As with all other products we use a two stage differentiation protocol to enable investigators to chose the optimal starting material and switch at a later stage with confidence that results they obtain can be compared. It is the same reason xCell offers isogenic pairs of cells and protocols for co-culture and medium optimized to maintain co-cultures for prolonged time periods.

For electrophysiology experiments, XCell recommends Brain Phys medium developed by Stem cell technologies. XCell offers custom derivation services  for specific neuronal lineages including spinal motoneurons and serotinergic neurons. 

Control Lines

Product Description Reprogram Method Source
XCL-1 Male Control Line Episomal Vectors Cord blood cells CD34+
XCL-6 Female Control Line Episomal Vectors Cord blood cells CD34+

Knockout Lines

Product Description Associated Disease Parental Line
SOD1-/- Custom Request ALS XCL-1
SOD1+/- Custom Request ALS XCL-1
APOE-/- Custom Request Alzheimer's Disease XCL-1
PINK1 -/- Custom Request Parkinson's Disease XCL-1
CNTNAP2 +/- Custom Request Autism XCL-1
BDNF-/- Custom Request CNS in General XCL-1
BDNF+/- Custom Request CNS in General XCL-1
LRRK2-/- Custom Request Parkinson's Disease XCL-1
LRRK2+/- Custom Request Parkinson's Disease XCL-1
PARK2-/- Custom Request Parkinson's Disease XCL-1
PARK2+/- Custom Request Parkinson's Disease XCL-1
PINK1 -/- Custom Request Parkinson's Disease XCL-1
PINK1+/- Custom Request Parkinson's Disease XCL-1
PARK7-/- Custom Request Parkinson's Disease XCL-1
PARK7+/- Custom Request Parkinson's Disease XCL-1
PARK2-/-;PINK1-/- Custom Request Parkinson's Disease XCL-1
PARK2-/-;PARK7-/- Custom Request Parkinson's Disease XCL-1
DISC1-/- Custom Request Schizophrenia XCL-1

Reporter Lines

Product Description Parental Line
AAVS-DCX-GFP Custom Request XCL-1
CAG-GFP-chr13-hetero Custom Request XCL-1
CAG-GFP13-RFP19-hetero Custom Request XCL-1
CAG-GFP-chr19-hetero Custom Request XCL-1
CAG-GFP-chr19-homo Custom Request XCL-1
GFAP-NanolucHalotag-hetero Custom Request XCL-1
MAP2-NanolucHalotag-hetero Custom Request XCL-1